Replicating both ways

Barcan Both Ways

Does COPI Go Both Ways?

from one Golgi complex to another under conditions that * Department of Molecular Cell Biology mirrored the conditions required for vesicle formation, Howard Hughes Medical Institute docking, and fusion. However, to many investigators University of California in the field, it remained uncertain whether the vesicles Berkeley, California 94720-3202 represented an obligatory intermediate in intra-...

IFT-A goes both ways

Protrusion provides a prognosis H ow a cancer cell migrates across a 2D surface says little about its ability to move through a 3D matrix, Meyer et al. reveal, but measuring membrane protrusion can be much more informative. A metastasizing tumor cell moves through 3D tissues, yet, largely because they're easier to perform, most studies of cell migration are carried out on 2D surfaces. Meyer et ...

Gene Silencing CUTs Both Ways

There is extensive transcription throughout the eukaryotic genome resulting in both antisense transcripts from coding regions and cryptic unstable transcripts (CUTs) from intergenic regions. In this issue, Camblong et al. (2007) demonstrate in the budding yeast that antisense transcripts, if stabilized by exosome impairment, are able to mediate gene silencing via the recruitment of histone deac...

C. elegans Aging: Proteolysis Cuts Both Ways

Recent reports from two laboratories working on the nematode Caenorhabditis elegans have identified both positive and negative roles for ubiquitin-mediated proteolysis in the regulation of longevity by the insulin/insulin-like growth factor signaling pathway.